第十六届共济失调性毛细血管扩张症研讨会（Ataxia-Telangiectasia Workshop, ATW-2015）暨第六届DNA损伤应答与人类疾病国际研讨会（international symposium on DNA Damage Response & Human Disease, isDDRHD-2015）将于2015年10月11-14日在首都师范大学召开，这是从1980年起不定期在世界各地举办的ATW与由首都师大DNA损伤应答北京市重点实验室于2010年创办的isDDRHD年会系列联合的国际会议。本次会议由首都师大DNA损伤应答北京市重点实验室、北京细胞生物学会、德国Fritz Lipmann研究所、中国细胞生物学会信号转导分会共同主办。

共济失调性毛细血管扩张症（A－T）的致病基因编码调控DNA损伤应答的核心激酶ATM，A-T病人的核心特征之一是对DNA损伤非常敏感。因此，ATW-2015/isDDRHD-2015的主题包括A-T疾病的生物学基础与临床、ATM/ATR介导的DNA损伤应答、基因组不稳定性与癌症及神经退行性病变等。本次大会将邀请50名国内外知名专家做大会交流，包括大会keynote speakers Drs. Tanya Paul和Howard M. Lederman、EMBO keynote speaker Dr. Yosef Shiloh，并将从递交的摘要中遴选10份作为大会口头报告，为青年学者提供10个名额的旅行资助（每人500美元），设置6个poster awards（每个300美元，其中两个是EMBO poster awards），这些机会将为本领域的年轻科学工作者提供向国际上一流科学家学习和展示自己工作的机会。

October 11th, Sunday, 2015

16:00-18:00 
Keynote speeches

16:00-17:00
Tanya Paull (USA): ATM activation and oxidative stress responses 

17:00-18:00
Howard M. Lederman (USA): Clinical Care of People with A-T: Two Decades of Progress

18:30
Welcome reception

October 12th, Monday, 2015

08:30-08:45
Opening ceremony

08:45-12:05
Neurodegeneration in A-T (I)

EMBO Keynote Speech

08:45-9:10
Yossi Shiloh (Israel): Ataxia-telangiectasia: attempting to understand the cerebellar phenotype

09:10-09:35
Peter McKinnon (USA): ATM Function in the Nervous System 

9:35-10:00
Keith Caldecott (UK): PARP1 and DNA single-strand break induced neurological disease 

10:00-10:30 
Group photo and tea break

10:30-10:55
Penny Jeggo (UK): Adult neuronal stem cells sensitively activate ATM dependent apoptosis 

10:55-11:20
Ari Barzilai (Israel): The role of Atm in brain functionality

11:20-12:05
Selected talks (3 × 15’)

12:05 Lunch

13:00-14:30
Neurodegeneration in A-T (II)

13:00-13:25
Zhao-Qi Wang (Germany): MRN in neurodelgeneration

13:25-13:50
Karl Herrup (HK): Back to the future: the role of ATM in late-onset neurodegenerative disease 

13:50-14:15
Martin Lavin (Australia): Rat model for ataxia telangiectasia

14:15-15:00
Selected talks (3 × 15’)

15:30-17:30
Poster session I (odd-numbered posters)

17:30-19:30
Poster session II (even-numbered posters)

19:30 Dinner hosted by CNU

October 13th, 2015

08:00-09:40
DNA damage response and cancer (I)

08:00-08:25
Fred Alt (USA): Role of the ATM DNA DSB Response Pathway in IgH CSR, Chromosomal Translocations and Lymphoma

08:25-08:50
Cong Liu (China): A CRL4 ubiquitin ligase facilitates chromatin recruitment of Exo1 to promote long-range resection of double strand breaks

08:50-09:15
Jun Huang (China): A novel helicase in DNA repair

09:15-09:40
Jan Karlseder (USA): Telomere function during senescence and crisis 

09:40-10:00
Tea break

10:00-12:30
Therapy for A-T

10:00-10:25
Luciana Chessa (Italy): New insight in the steroid therapy of Ataxia Telangiectasia 

10:25-10:50
Tom Crawford (USA): Advances in clinical neurology assessments of A-T at Johns Hopkins 

10:50-11:15
Domenico Delia (Italy): Activity-dependent responses and transcriptional regulation in iPSC-derived neurons from A-T patients 

11:15-12:40
Malcolm Taylor (UK): The increasing range of clinical and cellular variation in ataxia telangiectasia

12:40-12:05
Pat Concannon (USA): Exome sequencing of subjects with unexplained radiation sensitivity identifies novel genes that affect DNA damage responses

12:05-12:30
Tanja Stankovic (UK): Targeting ATM loss in sporadic haematopoietic malignancies

12:30 Lunch

Social Event 

19:00 Dinner

October 14th, Wednesday, 2015

08:00-12:00
ATM-dependent DNA damage response

08:30-08:55
Mike Kastan (USA): ATM: Beyond DNA damage signaling 

08:55-09:20
Axel Behrens (UK): Mechanisms and functions of ATMIN-dependent ATM signaling 

09:20-09:45
Susan Lees-Miller (Canada): New role for DNA-PKcs and ATM in mitosis

09:45-10:10
Kenshi Komatsu (Japan): Roles of NBS1 in radiation-induced chromatin remodeling and a response to UV damage

10:10-10:40
Tea break

10:40-11:05
John Tainer (USA): Mre11-Rad50-Nbs1 functional interactions with ATM and other partners 

11:05-11:30
John Petrini (USA): Nbs1 and the regulation of Mre11 complex-dependent DDR signaling 

11:30-12:00
Selected talks (2 × 15’)

12:00 Lunch

13:00-15:05
ATM-ATR coordinating DNA damage response

13:00-13:25
Lee Zou (USA): Orchestrated Functions of ATM and ATR in DNA Repair 

13:25-13:50
Daochun Kong (China): The intra-S phase checkpoint regulates the replicative helicase CMG complex to stabilize stalled replication forks 

13:50-14:15
Marco Fioani (Italy): Metabolic pathways influencing the DNA damage response: the impact of ATR and ATM

14:15-14:40
Xingzhi Xu (China): Reversible ubiquitination in the replication stress response

14:40-15:05
Kum Kum Khanna (Australia): Single-stranded DNA binding proteins and integrator complex at crossroads of transcription and maintenance of genomic stability

15:05-15:35
Tea break

15:35-17:40
DNA damage response and cancer (II)

15:35-16:00
Qimin Zhan (China): Cell cycle regulator Nlp in the control of mitotic progression and genomic stability

16:00-16:25
Junjie Chen (USA): Protein-protein interaction network in DNA damage response and tumorigenesis

16:25-16:50
Tej Pandita (USA): Role of Chromatin structure in DNA DSB repair pathway choice 

16:50-17:20
Selected talks (2 × 15’)

17:20-17:45 
Andre Nussenzweig (USA): Tumor promoting role of the DNA damage response

17:45-18:10
Steve West (UK): Regulatory control of DNA repair by homologous recombination

18:10-18:30 
Poster awards and closing remarks

18:30
Farewell dinner

学生或博士后每人1200元；教师或工作人员每人1800元。包含会议资料和10月12-14日的午餐和晚餐。