Paul Teesdale-Spittle

Paul Teesdale-Spittle简历

Paul Teesdale-Spittle, Professor of Victoria University of Wellington, Lower Hutt, New Zealand. His research is primarily focused on the design, synthesis and evaluation of compounds for the treatment of cancer and parasite infection. To this end, he make use of computational techniques (including molecular modelling of ligand-target interactions and structure activity relationship analysis), chemical synthesis (by solution and solid phase techniques, including parallel combinatorial synthesis), and in vitro assays.Current projects involve inhibitors of glutathione S-transferase enzymes as antiparasitic agents, peloruside and its analogues and bioreducible anthraquinone N-oxide topoisomerase inhibitors as anticancer agents. He is also interested in understanding and harnessing WW domains, which are associated with protein recognition and binding.