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美国哥伦比亚大学Alumni教授Robert照片

Robert简历

The focus of Dr. Kass' research program is the structure and function of ion channels that are expressed primarily in the heart. The laboratory most recently has focused on understanding the molecular physiology and pharmacology of congenital arrhythmias. These arrhythmias are caused by inherited mutations in genes coding for ion channels and/or ion channel related proteins expressed in the heart. This work has contributed to an understanding of gene-specific risk factors caused by mutation-induced changes in heart ion channel activity, and to the development of a mutation-specific approach to manage these disorders. The mutation-specific therapeutic strategy, verified in genotyped patients, has established the principle that two variants of the same genetic disorder require dramatically different therapeutic strategies for disease management based on biophysical properties of specific genetic lesions. This approach has evolved from close collaborations with clinical colleagues in which information is shared from clinic to basic laboratory and back to clinic. Additional studies are aimed at unraveling the structural basis of mutation-induced, and potentially lethal, disease phenotypes using approaches such as voltage-clamp fluorometry to directly measure movement of gating machinery in the ion channel of interest as well as biochemical methods of directly probing structures of region of ion channels that are hotspots for disease-causing mutations and the use of computer-based modeling to understand both structure and functional consequences of these mutations. The goal of this approach is to unmask new and specific targets for the development of anti-arrhythmic drugs.

出席会议历程

2016-09-19
2015-12-04
  • 第十届国际湿地大会

    地点:苏州

    此次大会将为研讨有关湿地生物多样性、湿地生态系统管理、以及湿地在废水处理、生态系统服务和其他方面的广泛应用提供交流的平台。

    报名截止
  • 2015第七届国际心脏病大会(ICC)

    地点:上海

    本次大会以“为生命注入新活力”为主题,将延续其以往鲜明的专业化、国际化特色,并对大会内容做进一步的充实和完善。

    报名截止

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